The invention relates to a preparation method of 1chloroethyl cyclohexyl propyl carbonate and belongs to the field of chemicals. Candesartan cilexitil trityl candesartan trityl candesartan cilexetil 1chloroethyl cyclohexyl carbonate canigliflozin 5bromo2methylbenzoic acid 2,3,4,6tetrakisotrimethylsilyldgluconolactone. The invention discloses a synthesis method of candesartan cilexetil. Potential reagents for the ndemethylation of tertiary amines were screened in order to produce drug metabolite reference material for forensic toxicological applications, and 1chloroethyl chloroformate was found to be the reagent of choice. Cyclohexyl 1chloroethyl carbonate 99464832 c9h15clo3 206. A novel and practical synthesis of substituted 2ethoxy. Candesartan is marketed as the cyclohexyl 1hydroxy ethyl carbonate cilexetil ester, known ascandesartan cilexetil.
Manufacturing of organic intermediates like isocyanates, chloroformates and carbonyl chlorides is our expertise. Development and manufacturing of phosgene based speciality chemicals and intermediates is paushaks core competencies. X is a direct bond or a spacer having an atomic length of two or less. Industrially, chloromethyl chloroformate is used to. Structure, properties, spectra, suppliers and links for.
The present invention provides an improved process for the manufacture of candesartan cilexetil form i. For example, our acrylic urethane and silicone coating resin and formulation expertise has been used to develop innovative solutions for releaseliners on paper and decorative coatings on plastic film. The candesartan cilexetil is synthesized by esterification reaction, reduction reaction, carbalkoxylation reaction, nitration reaction, nalkylation reaction, catalytic hydrogenation reaction, cyclization reaction, hydrolysis reaction, condensation reaction and deprotection reaction. It is a colorless liquid with a penetrating, irritating odor. Product and company identification product name 1chloroethyl cyclohexyl carbonate product code 32540502,32940505 cas no 99464832. Antibacterial solid composition for oral administration. Identification of new processrelated impurity in the key. Method development and validation by gcms for quantification of 1. Candesartan cilexetil is metabolised completely by esterases in theintestinal wall during absorption to the active candesartan moieity. Cn104496822a preparation method of 1chloroethyl cyclohexyl. It is a tearing agent designed to cause temporary blindness. Summary of particularly hazardous substances alphabetical key. An antibacterial solid composition for oral administration which comprises a lipid soluble cephalosporin compound having an noctanolwater partition coefficient of about 100 to 1,000 in a proportion of about 20 to 95 percent by weight relative to the composition, and.
Pdf identification of new processrelated impurity in. You can also browse global suppliers,vendor,prices,price,manufacturers of 1chloroethyl cyclohexyl carbonate99464832. Chloroethyl chloroformate 2chloroethyl chloroformate. Please post your buying leads,so that our qualified suppliers will soon contact you. Identification of new processrelated impurity in the key intermediate. Sds of 1chloroethyl cyclohexyl carbonate, safety data. To view a pdf file of a technical data sheet tds or material safety data sheet msds, click on the corresponding download link. The use of a prodrug form increases the bioavailability of candesartan. It is available as a prodrug in the form of candesartan cilexetil.
The reaction was performed by refluxing in dry 1,2dichloroethane under nitrogen, and the carbamate intermediate was hydrolysed by treatment with methanol. A clear, colourless to pale yellow or brownish liquid used as an intermediate for apis such as cefotiam and candesartan. For more information, please view spec of 1chloroethyl cyclohexyl carbonate 99464832. Application specification ertapenem side chain 202467694 for ertapenem 98%min meropenem side chain 96034649 for meropenem 98%min betamethyl vinyl phosphate map 90776593 for meropenem 98%min biopenem side chain 153851719 for biopenem 98%min. Predicted data is generated using the us environmental protection agencys episuite. To view a pdf file of a technical data sheet tds or material safety data. Compound 12 chloroethyl 3cyclohexyl1nitrosourea with free spectra. Srinivasarao, method development and validation by gcms for quantification of 1chloroethyl cyclohexyl carbonate as a genotoxic impurity in candesartan cilexetil drug substance, int. Specialty resins, intermediates and additives phichem.
Industrial chemical engineering acetic acid alcohol. The clp regulation makes sure that the hazards presented by chemicals are clearly communicated to. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. Chloromethyl chloroformate cclo 2 ch 2 cl is a chemical compound developed for use in chemical warfare in world war i.
Chemicalbook provide chemical industry users with 1chloroethyl cyclohexyl carbonate boiling point melting point,1chloroethyl cyclohexyl carbonate density msds formula use,if you also need to 1chloroethyl cyclohexyl carbonate other information,welcome to contact us. Scselect carcinogens rt reproductive toxins atacute toxins sareadily absorbed through the skin revised. Vandemark products are listed below by product categories. Visit chemicalbook to find more 1chloroethyl cyclohexyl carbonate99464832 information like chemical properties,structure,melting point,boiling point. Cyclohexyl 1 chloroethylcarbonate 99464 83 2 canagliflozin intermediates 2 4 fluorophenyl5 5 iodo2methylbenzylthiophene 898566 17 1. Articles of 1chloroethyl cyclohexyl carbonate are included as well.
Home chemical listing c 1chloroethyl cyclohexyl carbonate 1chloroethyl cyclohexyl carbonate 99464832 list of suppliers after selecting multiple suppliers. Cyclohexyl 1chloroethyl carbonate cyclohexyl 1chloroethyl carbonate. Risk assessment and hazard evaluation activities relating to chemical contaminants in drinking water. Visit chemicalbook to find more 1chloroethyl cyclohexyl carbonate99464832 information like chemical properties,structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Cheoroethyl cyclohexyl carbonate appearance uses clear liquid with pungent odor physical properties density. Further disclosed is a candesartan cilexetil preparation containing less than 0. Data sheet nr 3600 j 1chloroethyl cyclohexyl carbonate. The clp regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the european union through classification and labelling of chemicals. Cn102887890a synthesis method of candesartan cilexetil. Despite this, absolute bioavailability is relatively poor at 15%. It also can be called carbonic acid, 1chloroethyl cyclohexyl ester. Remarkably, the ester 20 could also be obtained from compound 18 in one pot with the same result. Cecc 1chloroethyl cyclohexyl carbonate 99464832 cecf 1chloroethyl chloroformate 50893533 ceec 1chloroethyl ethyl carbonate 50893362 cefaclor 53994733 cefadroxil 50370122 cefamandole nafate 42540409 cefazolin acid 25953199 cefazolin sodium lyophilized sterile 27164461 cefdinir monohydrate 91832405.
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